150,000 IU vitamin D before an ultramarathon reduces bone breakdown 🦴
Super high dose vitamin D for ultra endurance athletes.
Single high-dose vitamin D supplementation impacts ultramarathon-induced changes in serum levels of bone turnover markers: a double-blind randomized controlled trial
Study Details
This new study recruited 35 semi-professional male trail runners to ingest a single dose of either…
☀️ 150,000 IU vitamin D3
💊 Placebo
…24-hrs before the start of a 240-km ultramarathon ⛰️
Markers of bone turnover were assessed via blood sample…
↩️ Pre-supplementation (“pre-race”)
🏁 Immediately post-race
⏰ 24-hrs post-race
Here is what they found ⬇️
Key Findings
After the run in both groups…
🩸 N-terminal propeptides of type I collagen (a marker of bone formation) 🩸
…was increased immediately after 🏃♂️
However, the increase was significantly higher in the supplemented group 📈
At 24-hrs post-run markers of bone breakdown and inflammation including…
🦴 CTX
🦴 PTH
🦴 sclerostin
🦴 procalcitonin
…were significantly elevated in the placebo group only ⚠️
Conclusion
For prolonged / intense exercise (like ultramarathons) a high-dose of vitamin D may support bone health and attenuate bone breakdown ✅
These findings indicate a protective role of vitamin D3 against exercise-induced bone and inflammatory stress 🛡️
Reference
https://pubmed.ncbi.nlm.nih.gov/40963202/
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