Biomarkers of exercise-induced gastrointestinal syndrome and symptoms 🧬
Should you be monitoring these biomarkers?
The Relationship Between Biomarkers of Exercise-Induced Gastrointestinal Syndrome and Exercise-Associated Gastrointestinal Symptoms
Study Details
This new study examined links between exercise-induced gastrointestinal syndrome, inflammation and gastrointestinal symptoms during heat stress 🌡️
56 non-acclimated endurance athletes completed prolonged steady-state running in hot conditions 🚴
Blood markers of gut epithelial injury and systemic inflammation were measured before and after exercise 🔍
Gastrointestinal symptoms were recorded regularly during exercise 📝
Key Findings
🩸 IL-6 was associated with defecation and bloody stools
😖 IL-10 was associated with upper abdominal pain
💨 IL-10 and IL-1ra were associated with flatulence
🔥 The systemic inflammatory response profile was associated with flatulence
💩 IL-6 independently explained some of the variation in defecation and bloody stools
💨 IL-10 and IL-1ra independently explained some of the variation in flatulence
Conclusion
Exercise-associated gastrointestinal symptoms during heat stress appear to have multiple causes 👈
GI symptoms do not always reflect the full level of gut disruption occurring during exercise in the heat 🚨
Symptom reporting alone may underestimate gastrointestinal perturbation during exertional heat stress 📝
Reference
https://pubmed.ncbi.nlm.nih.gov/42347472/
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