Genetic performance differences with caffeine supplementation 🧬☕️
Are you a fast or slow caffeine metaboliser?
CYP1A2 Genotype and the Ergogenic Effect of Acute Caffeine Intake on Muscular Strength and Endurance Performance in Trained Individuals
Study Details
This new study investigated whether the effects different genotypes of CYP1A2…
…affects the ergogenic effects of caffeine on muscular strength and endurance performance in resistance-trained men and women 🔍
Participants were split by genotype into either…
1️⃣ AA - fast caffeine metabolisers
2️⃣ AC - intermediate caffeine metabolisers
3️⃣ CC - slow caffeine metabolisers
Supplementation was 3 mg/kg prior to standardised bench press and back squat tests 💊
Key Findings
Caffeine significantly improved strength and muscular endurance performance across conditions 📈
In the strength testing, mean velocity increased by…
👉 4% - 12% in AA
👉 3% - 9% in AC
👉 ≤ 4% in CC
In the muscular endurance test, mean velocity improved by
👉 4% - 6% in AA
👉 3% - 4% in AC
👉 2% - 6% in CC
Although CYP1A2 genotype did not alter the overall ergogenic effect of caffeine, benefits were…
🥇 Greatest in AA
🥈 Intermediate in AC
🥉 Minimal in CC carriers
Conclusion
Caffeine is likely to enhance performance regardless of genotype, yet there may be some individuals variability explained by these polymorphisms ✅
Reference
https://pubmed.ncbi.nlm.nih.gov/41627185/
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