Taurine may attenuate muscle loss during disuse 💪

A new strategy for muscle retention?

Taurine Attenuates Disuse Muscle Atrophy Through Modulation of the xCT-GSH-GPX4 and AMPK-ACC-ACSL4 Pathways

Study Details

Taurine has been shown to improve proliferation and myogenic differentiation potential of myoblasts (aka support muscle maturation) 📈

This new study investigated the effects of daily taurine supplementation on muscle atrophy during simulated disuse in rats 🐀

After 5-weeks, muscle characteristics, markers of atrophy and performance was assessed 🔬

Here is what they found ⬇️

Key Findings

Taurine supplementation led to significantly improved…

👉 Muscle strength

👉 Muscle retention

…while attenuating markers of muscle cell death 📉

Metabolomic analysis suggested that taurine modulates disorders in glutathione and lipid metabolism 🧬

…which may have been responsible for stopping muscle and strength loss 🛡

Conclusion

Taurine may play a protective role for skeletal muscle during periods of disuse (e.g. injury, detraining) ✅

Although this is preliminary evidence from rats and definitive conclusions for humans are limited ⚠️

Interesting finding nonetheless, and we may start to see human evidence of this effect in the near future 🧐

Reference

https://pubmed.ncbi.nlm.nih.gov/40722950/

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